MFSD8 and Brain atrophy: Additionally, MRI findings indicated generalized brain atrophy and enlarged lateral ventricles, and tissues at necropsy showed evidence of storage material accumulation in both CNS and heart, lack of frank cell loss but a reduced neuronal density in the cortex, granular and Purkinje cell loss in the cerebellum and retinal degeneration and gliosis, sharing many of the same pathological features as the CLN7−/− macaques described here.