The Japanese macaque CLN7−/− disease phenotype that we characterized closely parallels the course of disease seen in children with the CLN7 form of Batten disease, including vision decline, tremor, hindlimb weakness, ataxia, incoordination, hypermetria, along with bradykinesia at later stages of disease (Table 2). This evidence concerns the gene MFSD8 and juvenile neuronal ceroid lipofuscinosis.