These mice were found to have a similar level of LV dilatation and reduced fractional shortening to Csrp3-/- mice at 2 months of age (Fig. 4, Table S6), indicating that the Csrp3 C58G allele cannot functionally compensate for the loss of the Csrp3 WT allele on the Csrp3 null background. Here, CSRP3 is linked to Vascular dilatation.