Additionally, changes indicative of cardiac hypertrophy and heart failure, e.g. Fhl1 upregualtion and Fhl2 downregulation [25, 26], Carp induction [27]) and upregulation of β-myosin heavy chain [28] were observed at the protein level in the myocardium of KI/KI mice. This evidence concerns the gene FHL1 and heart failure.