Inactivation of both alleles of the Csrp3 gene (Csrp3-/-; also known in the literature as MLP knock out, KO, mice) leads to a striking cardiac phenotype resembling DCM [7], while hemizygous Csrp3+/- have normal cardiac dimensions and function at baseline ([17] and Fig. 4 and Fig. S7B, Table S5). The gene discussed is CSRP3; the disease is familial dilated cardiomyopathy.