The prescription of loop diuretics (oral furosemide 80 to 240 mg/day) combined or not with thiazide diuretics (oral hydrochlorothiazide or chlorthalidone 25 to 50 mg/day) is a powerful tool to manage edema and decrease blood pressure levels.37,38 However, imprudent use of diuretics may cause hypovolemia, intensification of cramps, hypo- or hypernatremia, hypokalemia, and impaired management of calcemia.39 Potassium-sparing diuretics and renin inhibitors must be prescribed cautiously, since they favor the development of hyperkalemia.39 This evidence concerns the gene REN and Hyperkalemia.