The management of anemia through iron replacement accompanied or not by erythropoietin is a powerful tool in providing relief against symptoms such as lethargy, fatigue, and inability to focus.33 The guidelines have recommended that hemoglobin levels be kept between 10 and 12 g/dl34; however, levels in the range of 12 to 13 g/dl are more effective in managing symptoms and have been associated with improved quality of life, two important variables in conservative care without dialysis.35 The gene discussed is EPO; the disease is anemia (phenotype).