This conclusion is supported by the results that Hemin treatment or Ad-HO-1 infection reversed the decreased eNOS phosphorylation at Ser1177 induced by H2O2 while HO-1 silencing restrained this phosphorylation, and that HO-1 did not alter either the total expression of eNOS nor the phosphorylation at Thr495. Here, HMOX1 is linked to infection.