TRIM5 and myeloid sarcoma: However, the negative association between SNPs in both tripartite interaction motif 22 (TRIM22) and TRIM5 and the risk of developing MS could plausibly stem from altered regulation of RIG-I and mitochondrial antiviral signalling-5 (MAVS-5), or other cytosolic pattern recognition receptors in response to HERV RNA, as we now move to discuss.