Several other research teams have also reported a negative association between SNPs in the tripartite motif-containing (TRIM) protein-encoding genes TRIM5 and TRIM22 on chromosome 11 and MS susceptibility, and a positive association with the SNP rs391745, one of a cluster of SNPs in a region lying upstream of the HERV-Fc1 locus on the X chromosome [40, 85, 86]. Here, TRIM5 is linked to myeloid sarcoma.