This latter finding has also been observed in brain tissue of MS patients and in mice with experimental autoimmune encephalomyelitis (EAE), in which HERV-W overexpression was associated with the development of neuroinflammation and damage to oligodendrocytes and myelin mediated by nitric oxide, peroxynitrite and other redox-active molecules [171, 172]. The gene discussed is ERVW-1; the disease is myeloid sarcoma.