Histone acetyltransferase P300/CBP-associated factor (PCAF) was shown to become recruited to promoters by the histone remodeling factor Cockayne syndrome B (CSB) where it acetylates histones H3 and H4, which is required for the assembly of the Pol I initiation complex (Shen et al. 2013). The gene discussed is KAT2B; the disease is Cockayne syndrome.