MMP‐13 is up‐regulated in inflammation, and is elevated in the atherosclerotic plaque, contributing to its vulnerability.1 It is also implicated in the progression and remodelling of cerebral tissue in stroke.2 Plaque rupture releases MMP‐13 into the local environment where it has direct access to plasma proteins, blood cells, and platelets. The gene discussed is MMP13; the disease is Stroke.