In the present study, we have used antisense LNA GapmeRs to inhibit lncRNA PVT1 in acute erythroleukemia (AEL, also known as AML M6) cell line (KG-1) and its effects on the apoptosis and necrosis of KG-1 cells were assessed. The gene discussed is PVT1; the disease is acute myeloid leukemia.