Considering the study group (CAD group vs. control group) as the dependent variable and age, sex, TG, TC, HDL-C, LDL-C, smoking, diabetes, hypertension and ABCA1 methylation status as covariates, the methylated state of ABCA1 was identified as a significant and independent risk factor for CAD development (OR=2.68, 95% CI: 1.12-7.13; P=0.028). The gene discussed is ABCA1; the disease is diabetes mellitus.