miR-155 was reported to promote invasiveness of pancreatic cancer cells, through regulating suppressor of cytokine signaling 1 (SOCS1) and P-signal transducer and activator of transcription-3 (STAT3) [186], and promote the hepatocellular carcinoma progression by targeting PTEN [187]. Here, STAT3 is linked to familial pancreatic carcinoma.