TLR4 and familial pancreatic carcinoma: It was reported that miR-203 was present in pancreatic cancer cell derived exosomes, and miR-203 suppressed the expression of toll-like receptor 4 (TLR4) resulting in the decreased levels of tumor necrosis factor-α (TNF-α) and interleukin-12 (IL-12) in pancreatic cancer cell line Panc-1 [92].