Recently, betulin, an immunomodulatory compound extracted from Hedyotis hedyotidea, was shown to be able to ameliorate concanavalin-A-induced autoimmune hepatitis in mice through inhibition of NKT cells- and T cell-derived IFN-γ, TNF-α, and IL-6 cytokine expression [155]. The gene discussed is IFNG; the disease is autoimmune hepatitis.