It has not yet been established where in the metastatic cascade TEM8 plays a role, and in order to investigate TEM8’s role in metastasis further, it would be interesting to assess the different metastatic steps; invasion (tumor cells escaping the primary tumor), circulation in the bloodstream, extravasation at secondary sites and initiation of angiogenesis at secondary sites [8]. This evidence concerns the gene ANTXR1 and neoplasm.