For example, cholangiocarcinoma (CHOL) overexpresses a large variety of subunits (e.g. ITGAV, ITGA1, ITGA4, ITGA5, ITGA11, ITGB1, ITGB2, ITGB6), whereas, the equally deadly pancreatic adenocarcinoma (PAAD) overexpresses a very limited set of integrins, including ITGA6 and ITGB4. This evidence concerns the gene ITGB4 and pancreatic adenocarcinoma.