SETD2 and brain neoplasm: Concerning the functional significance of the G34R/V in childhood brain tumors it has been hypothesized that the proximity of H3G34 and H3K36 might play a major role: H3K36 represents a residue that regulates transcriptional elongation, and H3G34R/V mutant nucleosomes have been shown to carry reduced methylation of H3K36 by SETD2, the only human methyltransferase specific for H3K36 [22].