Discovered on gastrointestinal stromal tumours 1 (DOG1) was initially described as a highly expressed calcium-dependent chloride channel in gastrointestinal stroma tumors (GIST) [28] and shown to serve as a sensitive diagnostic marker, particulary in PDGFRA-mutated tumors (wild-type for KIT) [29]. Here, ANO1 is linked to gastrointestinal stromal tumor.