Among patients with stage II and III CRC, the liver recurrence rate was significantly higher in those who showed PROK2 expression in the primary tumor than in those who did not show PROK2 expression (stage II: 21.1% vs. 8.2%, p = 0.016; stage III: 33.6% vs. 21.4%, p = 0.022). The gene discussed is PROK2; the disease is colorectal carcinoma.