The univariate analysis showed that poor RFS in patients with CRC was associated with positive PROK2 expression (p = 0.001), histological type (p = 0.002), lymphatic invasion (p = 0.043), venous invasion (p = 0.043), and lymph node metastasis (p = 0.001) (Table 3). This evidence concerns the gene PROK2 and colorectal carcinoma.