We first evaluated the expression level of both Src and Akt proteins and their respective activated forms in the renal carcinoma cells 786-O VHL- cells, and its derivate containing a functional VHL construct HA-VHL (786-O VHL+), together with a normal renal cell line (RPTEC) (Figure 1A, Supplementary Figure 3). This evidence concerns the gene VHL and renal carcinoma.