SPAG6 and neoplasm: From the putative targets, we focused our study on those with tumour suppression function or those with drug metabolism-related functions, including RE1-silencing transcription factor (REST), sperm Associated Antigen 6 (SPAG6), phosphatase and tensin homolog deleted from chromosome 10 (PTEN), frizzled-1 (FZD1) and large tumor suppressor 2 (LATS2).