Interestingly, examination of breast cancer datasets using the Oncomine data repository (www.oncomine.org) revealed that the gene encoding fibulin-3, EFEMP1 is amplified in TNBC patients (n = 73), in contrast to the expression in ERα-positive (n = 452) or HER2 positive (n = 110) patient tumors (Figure 1B). The gene discussed is ESR1; the disease is breast cancer.