The results from our previous study showed that Lgr5 expression in neoplastic cells of CRC was significantly more often found at the invasive front than at the tumor center; high Lgr5 expression was also detected in the region of tumor budding (TB), residual cancer tissues surrounding the necrotic foci, and distant metastatic organs of 42 CRC cases staged as pTNM IV. The gene discussed is LGR5; the disease is cancer.