High Lgr5 expression was found in 39.3% (57/145) of TBs and significantly correlated to the TB grade (r = 0.19, P < 0.05) (Table 3), while a high TB grade was significantly correlated to the depth of invasion, lymph node metastasis, TNM stage, and perineural invasion (P < 0.01), but not to patient gender, age, tumor size, tumor location, differentiation and lymphovascular invasion (Table 4). Here, LGR5 is linked to Townes-Brocks syndrome.