It is of interest to note that hyperglycaemia-induced ROS generation activates NF-κB proinflammatory pathway [35] and the nuclear enzyme poly(ADP-ribose) polymerase-1 [8], which in turn increases the levels of proinflammatory cytokines, cell adhesion molecules, and iNOS [8]. This evidence concerns the gene NFKB1 and Hyperglycemia.