The present study acknowledges a limitation that should be stated, we just observed the mitochondrial dynamic change in the pathophysiology process of the transition of autoimmune myocarditis to DCM induced by TLR4 activation, and other aspects of MQC were not included in this study, such as antioxidant system, mitochondrial unfolded protein response, and autophagy (mitophagy), which all are intimately linked to mitochondrial dynamics. The gene discussed is TLR4; the disease is autoimmune myocarditis.