TLR4 activation upregulated the inflammatory factors (mainly TNF-α) and ROS stress and resulted in OPA1 dysfunction by inducing OMA1 and YME1L abnormal degradation, which may aggravate the mitochondrial dynamic imbalance and damage, promoting the progression of EAM to DCM. Here, YME1L1 is linked to familial dilated cardiomyopathy.