Our results showed that FZKA significantly induced the apoptosis in NSCLC cells (more than 50% when treated with 1.5 mg/mL FZKA) in a dose-dependent manner as shown in the right (A2 and A4) quadrants of the histograms, which were counted as apoptotic cells detected by the Annexin V-FITC/PI Apoptosis Detection Kit. The gene discussed is ANXA5; the disease is non-small cell lung carcinoma.