FOXO1 and glioblastoma: Therefore, based on literature and our preliminary results, we hypothesized that XHP might inhibit glioblastoma cells apoptosis resistance by inducing Akt and mTOR dephosphorylation, decreasing phosphorylation of FOXO1, causing FOXO1 nuclear transport and enhancing its transcriptional activity, and finally triggering U-87 MG cell apoptosis.