Indeed, anabscopal effect of STING agonist treatment has been previouslyreported.18,29,30 While it is an indirectevidence suggesting immunomodulatory role of STING agonist, our data from systemiccytokine analysis further explain the beneficial effects of STING agonist treatmentin reducing tumour burden in STING agonist-treated mice. The gene discussed is STING1; the disease is neoplasm.