Remarkably, transient depletion of neutrophils (depletion validated in LysM-GFP mice, Fig. S5) following a single injection of a depleting antibody (1A8 versus the appropriate isotype control 2A3) one day prior to infection of C57Bl/6 TNF-α−/− mice (high parasitemia model) using both the 1A8 or the RB6-8C5 depleting antibodies (in comparison with their respective isotype controls 2A3 and LTF-2) resulted in a significant reduction of parasitemia levels in peripheral blood as compared to isotype treated C57Bl/6 TNF-α−/− mice (Fig. 4). Here, TNF is linked to parasitic infectious disease.