The combination of N-terminal localized TOF-LisH motifs is a seldom used but highly effective means of localizing proteins to MTOCs: FOP family proteins including FOR20 and OFD1 are centriolar proteins conserved in diverse eukaryotes, and in humans, chromosomal translocation results in TOF-LisH-dependent retargeting of the tyrosine kinase domain of the FGFR1 receptor to the centrosome, and an atypical myeloproliferative disorder [1,2]. This evidence concerns the gene OFD1 and myeloproliferative disorder.