In BCR-ABL-positive chronic myeloid leukaemia cell lines, STI571 (also called imatinib or Glivec), an inhibitor of BCR-ABL oncoprotein, increases FOXO3a mediated apoptosis by triggering FOXO3a dependent cell cycle arrest and Bim expression [134]. Here, FOXO3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.