FOXO3 is an indirect target of BMS-345541 (a highly selective IKK inhibitor) in T-cell acute lymphoblastic leukemia (T-ALL) in which the expression of p21Cip1 is up-regulation by increased nuclear translocation of FOXO3a after treatment with BMS-345541. The gene discussed is FOXO3; the disease is T-cell acute lymphoblastic leukemia.