Notably, among the novel Braak-DMCGs in our top 200 DMCGs we found a marker near the APP gene (cg08866780, \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$p = 1.41 * 10^{-7}$$\end{document}p=1.41∗10-7, rank 111, Fig. 4c, Additional file 2: Table S18) one of the most relevant AD genes  [39, 115]. This evidence concerns the gene APP and Alzheimer disease.