We depicted a new molecular scenario in which curcumin, by up-regulating miR-22 expression level, elicits the decrease of IPO7 and consequently hinders the nuclear translocation of HIF-1α essential for its activity, thus affecting the metabolic enzyme profile of CML cells (Fig. 8). The gene discussed is HIF1A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.