To deeper define the molecular steps through which the HIF-1α/miR22/IPO7 axis mediates the curcumin effects on CML cells future research can be aimed to define the timing in which HIF-1α nuclear localization is modulated as well as to identify other interactors acting within this system. This evidence concerns the gene HIF1A and chronic myelogenous leukemia, BCR-ABL1 positive.