Similarly in CML it was demonstrated that curcumin treatment induced the decrease of BCR-ABL expression at both mRNA and protein level associated to a dose-dependent increase of PTEN and a decreased AKT phosphorylation and VEGF expression due to a selective packaging of miR-21 in exosomes [11]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.