In our previous papers we demonstrated that curcumin treatment of CML cells caused a selective sorting of active miR-21 in exosomes and a concomitant decrease of this miRNA in the cells thus leading to the upregulation of PTEN that in turn caused a decrease of AKT phosphorylation and VEGF expression and release. The gene discussed is PTEN; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.