Similarly in CML it was demonstrated that curcumin treatment induced the decrease of BCR-ABL expression at both mRNA and protein level associated to a dose-dependent increase of PTEN and a decreased AKT phosphorylation and VEGF expression due to a selective packaging of miR-21 in exosomes [11]. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.