Anyhow, in the view of the apparent increase in ADAM17 levels and decrease in ADAM10 protein levels in AD CSF, it is questionable whether an enzymatic activity assay for ADAM10 in CSF, based in the use of synthetic peptides (which can be cleaved by multiple proteases), should be used to measure changes in the CSF α-secretase activity of AD patients. The gene discussed is ADAM10; the disease is Alzheimer disease.