ADAM10 and Alzheimer disease: After assigning the different ADAM10 immunoreactive species present in CSF as full-length (~ 55 kDa, ADAM10f) or truncated (~ 50 kDa, sADAM10) mature species, as well as immature forms (~ 80 kDa, proADAM10), we assessed whether the concentrations of these species are altered in AD.