While reviewing the evidence for medications that reduced admissions, we also identified high- and moderate-quality evidence for three therapies that significantly increased hospital admissions: cyclooxygenase-2 (COX-2) inhibitors in patients for whom non-steroidal anti-inflammatory drugs (NSAIDs) were indicated, intermittent antipsychotic drug therapy in patients with schizophrenia and fluticasone in patients with COPD (Table 3). The gene discussed is PTGS2; the disease is schizophrenia.