To this end, we estimated the plasma levels of MMP-1, − 2, − 3, − 7, − 8, − 9, − 10, − 12 and − 13 by multi-plex ELISA in TB-DM (n = 64), TB (n = 24) and HC (n = 24) individuals (Fig. 1). The gene discussed is MMP1; the disease is diabetes mellitus.