IL-1β may promote atherosclerosis development through different biological functions[43] and lead to the production of several pro-inflammatory factors such as interleukin-6, fibrinogen, and C-reactive protein.[44] In addition, IL-1β + 3954C/T is related to increased IL-1β production.[14,40] All of the above studies support our meta-analysis findings that the T allele of IL-1β + 3954C/T significantly increases MI risk. This evidence concerns the gene CRP and atherosclerosis.