To determine if cultured neuroblastoma cells are permissive to Zika virus infection, we infected a panel of cultured neuroblastoma cells including both MYCN-amplified cells [IMR-32, SMS-KAN, and SK-N-Be(1)] and non-MYCN-amplified cells (SK-N-AS, LA-N-6, and CHLA-42), using Vero cells as infection controls. Here, MYCN is linked to Zika virus infectious disease.