TLR8 and Chagas disease: In attempt to evaluate the TLR8 and IFN-β participation in the development of the digestive form of Chagas disease, we analyzed the correlation between the mRNA expression of TLR8 and IFN-β with the rectum and sigmoid size, resulting in a positive correlation observed between TLR80020and IFN-β and rectum and sigmoid size (Fig 4A–4D).