DDIT3 and obesity due to melanocortin 4 receptor deficiency: We detected higher expression of Lox, lower expression of CHOP‐10 and Ocn and decreased bone formation in HFD mice femurs (Figure 5D), in line with reports that obesity is associated with decreased bone mass.52 However, the mechanism underlying how Lox up‐regulates CHOP‐10 expression is yet to be uncovered.