It has been demonstrated that male C57BL6 mice fed a high‐fat diet was associated with a reduced rate of bone formation and turnover28 by increasing the number of lineage committed adipogenic progenitors in murine marrow at the expense of osteogenic lineage commitment,29 which potentially explained the association between increased marrow adipose tissue and increased fracture risk in diseases such as osteoporosis.30, 31, 32 To determine the relationship between Lox and CHOP‐10 in vivo, HFD‐induced obesity and osteoporosis model was used in mice. Here, LOX is linked to obesity due to melanocortin 4 receptor deficiency.