PADI4 and Sepsis: PAD4 participates in post‐translational modifications of histones, one of the major focus areas of epigenetic research.2, 4 Citrullination of histones, in particular histone H3, is one of the major points for inflammatory signals that trigger the neutrophil response to infections.2, 3, 4, 5 Nevertheless, citrullinated histone H3 is also important in the development of neutrophils extracellular traps (NETs).5, 6 It has been reported that elevated levels of NETs in the plasma may predict multiple organ dysfunction and sepsis in trauma patients.6