Finally, to rule out any possible involvement of seizure modulation in the neuroprotective effects of MMP-12 inhibition, we also demonstrate neuroprotection of the MMP-12 inhibitor in a murine optic nerve crush (ONC) model, thus indicating that this property might apply to different neurological diseases/disorders characterized by an important inflammatory response and/or neuronal cell loss. The gene discussed is MMP12; the disease is nervous system disorder.