NR4A1 expresses in many cell types and mediates diverse biological processes.20, 21 Recent studies showed that NR4A1 together with two other family members (NR4A2 and NR4A3) played important roles in maintaining cellular energy homeostasis.22 It was reported that mice with genetic deletion of Nur77 exhibited increased susceptibility to diet‐induced obesity and insulin resistance.23 Some studies showed that NR4A1 had an inhibitory effect on obesity.23, 24, 25 However, the underlying mechanisms remain elusive. Here, NR4A3 is linked to obesity due to melanocortin 4 receptor deficiency.