However, in helminth‐endemic areas (especially rural areas of low socioeconomic status), this relationship often breaks down.89, 90 Furthermore, multiple epidemiological studies have shown a positive association between antihelminth IgE (ascariasis, schistosomiasis, filariasis) and wheeze and/or atopy.91, 92, 93, 94, 95 One of the reasons for discrepancies between IgE reactivity (against allergen or helminth) and allergy in high‐income versus helminth‐endemic areas might be due to cross‐reactivity of antihelminth IgE to certain allergens. The gene discussed is IGHE; the disease is ascariasis.