OGG1 and obesity due to melanocortin 4 receptor deficiency: The early studies have linked the accumulation of oxidized guanines to changes in molecular and biological processes, including development of the central nervous and cardiovascular system, Huntington’s disease, obesity-metabolic disorders, mitochondrial dysfunction, and decreased innate and allergic inflammation in OGG1-deficient/Ogg1 KO mice [73–76].