In HepG2, top CPs were “hereditary breast cancer signaling”, “NRF2- mediated oxidative stress response”, “role of BRCA1 in DNA damage response”, “ATM signaling”, “cell cycle control of chromosomal replication”, “estrogen mediated S-phase entry” and “GADD45 signaling” (Fig. 4). The gene discussed is GADD45A; the disease is breast cancer.