Mimotopes, which are modified mimics of natural epitopes, have been hypothesized to potentially trigger enhanced cellular or humoral responses, being capable of secreting response-specific cytokines, stimulating production of antibodies, having superior MHC-restriction capabilities and potentially developing immunological memory against targeted TAAs/TSAs, thus potentially preventing cancer occurrence or relapse (Oyarzun et al., 2015). This evidence concerns the gene HLA-C and cancer.