The main findings were five-fold: (1) a high Ang-1 density was associated with reduced lymphangiosis carcinomatosa and improved histological grading in iCC; (2) angiogenic TEMs and miRNAs were differentially expressed in iCC and HC; (3) associated with established tumour markers, tumour growth and lymph node involvement; (4) served as independent prognosticators and (5) impacted on survival rates. Here, ANGPT1 is linked to intrahepatic cholangiocarcinoma.