The expression levels of IL-1β, IL-6, IL-17, TNF-α, TGF-β, and α-SMA (as a myofibroblast marker) were all decreased by anakinra treatment, which suggested anti-inflammatory and antifibrotic effects of the IL-1Ra in this BLM-induced fibrosis model (Figure 5C). The gene discussed is TNF; the disease is fibrosis.