Consistent with the higher infiltration of immune cells, right-side colon cancers were associated with higher levels of immune activation; specifically, cytotoxic activity score (CYT, p = 7.73e−6) (Figure 2C), antigen presentation machinery (APM, p = 4.16e−5) (Figure 2D), interferon-γ signature (p = 0.0004) (Figure 2E), TIS (p = 6.942e−10) (Figure 2F), and CD8+ T-cell/Treg ratio (p = 7.51e−11) were higher (Figure 2G). This evidence concerns the gene CD8A and colonic neoplasm.