We identified the most favorable OS in the NKHi41BBHi and NKHiIFNAHi cohort, further implying a critical role of NK subsets in antitumor immunity in left-side CRC (Figure 3C; CD56bright NK cells combined with 4-1BB pathway, p = 0.000424, CD56bright NK cells combined with IFNA pathway, p = 0.00973 for left side and CD56bright NK cells combined with 4-1BB pathway p = 0.428, CD56bright NK cells combined with IFNA pathway p = 0.594). Here, IFNA1 is linked to colorectal carcinoma.