In this study, we confirm that, in comparison with healthy-PLTs, platelets from T2DM patients show: (a) higher aggregating response to agonists (b) higher basal and AA-induced production of ROS, (c) enhanced levels of COX-1 and (d) increased levels of phospho-AKT and phospho-ERK-2 upon stimulation with agonists, more in diabetic than healthy platelets, thus confirming the hyper-reactivity of diabetic platelets. Here, MAPK1 is linked to type 2 diabetes mellitus.