In rodents, liver Aqp9 is transcriptionally downregulated by insulin (Kuriyama et al., 2002), explaining why streptozotocin-induced type 1 diabetes in rodents (Carbrey et al., 2003) and insulin resistance in human (Rodríguez et al., 2014) are associated with an increase in the hepatic levels of AQP9. The gene discussed is INS; the disease is Insulin resistance.