As AQP3 expression is increased in mouse 3T3-L1 differentiated into adipocytes (Chiadak et al., 2016, 2017), and in epididymal and subcutaneous adipocytes from high-fat diet rats developing obesity (Méndez-Giménez et al., 2017), and thereby could be involved in adipose tissue hyperplasia during obesity, AQP3 might also become an additional interesting drug target for the treatment of obesity. This evidence concerns the gene AQP3 and obesity due to melanocortin 4 receptor deficiency.