However, depending on their genetic background, these Aqp7 deficient mice presented different phenotypes characterized by either normal glycaemia with underdetermined insulinemia (Skowronski et al., 2007), normal glycaemia with hyperinsulinemia (Matsumura et al., 2007), or hyperglycaemia and hyperinsulinemia (Hibuse et al., 2005). Here, AQP7 is linked to Hyperinsulinemia.