In rodents, liver Aqp9 is transcriptionally downregulated by insulin (Kuriyama et al., 2002), explaining why streptozotocin-induced type 1 diabetes in rodents (Carbrey et al., 2003) and insulin resistance in human (Rodríguez et al., 2014) are associated with an increase in the hepatic levels of AQP9. This evidence concerns the gene AQP9 and type 1 diabetes mellitus.