Therapeutic synergy between metformin, suppressing hepatic gluconeogenesis (Petersen et al., 2017) and restoring insulin secretion (Patanè et al., 2000; Richardson et al., 2006), and drugs, specifically decreasing aquaglyceroporin hepatic expression or activity, could be beneficial for the treatment of T2D characterized by increased hepatic gluconeogenesis and hepatic lipid accumulation leading to hepatic insulin resistance (Petersen et al., 2017). The gene discussed is INS; the disease is Insulin resistance.