The metabolic shift towards lipid use in the TA muscles in the ALS mouse model that ubiquitously express the SOD1 mutant gene (Gurney et al., 1994) is accompanied by lower levels of PFK activity in both presymptomatic and symptomatic stages of the disease (Palamiuc et al., 2015). Here, SOD1 is linked to amyotrophic lateral sclerosis.