AHR and breast cancer: These data might also implicate that breast cancer cell lines are different from the benign MCF-10A breast epithelial cells, where down-regulation of the AhR by RES significantly affect estrogen-metabolizing enzymes and cause a down-regulation of SULT1E1, particularly as SULT1E1 is not expressed in MCF-7 cells (Licznerska et al., 2017).